Objective To explore the feasibility and advantages of perioperative nutritional therapy and accelerated rehabilitation surgery in the perioperative application of colorectal cancer. Methods A retrospective analysis on 110 cases of cT1~4a N0~2M0 colorectal cancer patients was performed. According to the different perioperative measures, they were divided into two groups, nutrition & ERAS group (62 patients) and traditional treatment group (48 patients). Before operation, the patients in nutrition & ERAS group were screened and scored with preoperative nutritional status, and after treated by nutritional therapy, they werethen underwent laparoscopic radical surgery. During the operation, several measures would be performed including keep warmth during anesthesia, insert analgesic pump and remove the drainage tubes at early stage or even retain none tubes. Moreover, the gastrointestinal decompression tube was removed at early stage or not retain, and early off-bed activity and liquid diet would be encouraged to support treatment. What’s more, we tried our best to give them 5 days intravenous fluids supplement. On the other hand, the patients in traditional treatment group were treated with common perioperative measures. Then the data would be compared between two groups. Results The averaged time of exsufflation, infusion days and postoperative hospital stay in nutrition & ERAS group were (2.2±0.8) days, (5.8±1.2) days and (7.8±1.5) days respectively. And they were shorter than traditional treatment group significantly (P<0.05). Moreover, it showed less morbidity of pulmonary infection and abdominal infection, and less pain score in 5 days after operation (P<0.05). Conclusions The application of perioperative nutrition therapy and accelerated rehabilitation surgery could accelerate the rehabilitation of colorectal cancer.