To study the relationship between the cyclin D1(CCNDl)A870G gene polymorphism and age, sex, smoking, family history, pathological typing and tumor stage for the patients with colon cancer (in Baoding). Cyclin D1(CCNDl)A870G genotype wasdetermined by polymerase chainreaction (PCR) and restriction fragment length polymorphism analysis (RFLP) of DNA extracted from blood. The study included 200 colon cancer patients and 200 healthy control subjects. Genotype frequencies of patients and controls both conformed to the hardy equilibrium. The GG genotype significantly correlated with a history of heavy smoking and Hypercholesterolemia (P<0.05). We conclude that hypercholesterolemia and smoking may be a risk factor for colon cancer in the GG genotype of cyclin D1(CCNDl)A870G polymorphism, the frequency of AA genotype in patients with hereditary factors was significantly higher than that of other genotypes, (P<0.05). There was no significant difference in GG genotype between severe smokers and hypercholesterolemia patients (P>0.05). It can be concluded that genetic factors can be used as a risk factor for colon cancer in the AA genotype of cyclin D1(CCNDl)A870G polymorphism, which will provide a basis for further study on the molecular mechanism of colon cancer.