Objective To investigate the effect of ketogenic fat on body weight, body fat and visceral fat. Methods In this study, we recruited several volunteers whose meet the standard of clinical studies. According to the basic principle of the ketogenic diet, we manage diets of volunteers, measure body weight, skeletal muscle weight, body fat by body composition analysis, calculate waist hip ratio based on anthropometry data at regular intervals. Results From the the first week, body weight of volunteers has begun declined, accumulating weight reduction is （3.99±2.29）kg in 4 weeks, body fat reduction continued decline during ketogenic diet period, shows positively relationship: y=1.32423 0.37536*x, R2=0.81966. At the same time, ketogenic diets also can effectively reduce hip ratio dieters (y=0.016 0.00476*x, R2=0.61009). Conclusions the ketogenic diets has obviously affect on body fat reduction and waist to hip ratio decreased, and has positive correlation to time of duration. Ketogenic diet used in clinical treatment has lasted nearly a hundred years, its indications from epilepsy extended to weight reduction, tumor therapy, and so on.