Objective To evaluate the effects of four treatment options on the survival of patients with liver metastases from colon cancer. Methods Through searching PubMed, EMBASE, Cochrane Library, China Scientific Journals Network Publishing Library Weipu Chinese Science and Technology Journal Full-text Database, China Biomedical Literature Database, Wanfang Data Journal Paper Resources, China Scientific Citation Database and China Traditional Chinese Medicine Database, Clinical Trial Registration Institution Website and Google Academic Baidu Academic and other databases were searched for relevant literatures to obtain systemic chemotherapy, preoperative chemotherapy+surgery+postoperative chemotherapy, a clinical study on the treatment of liver metastases from colon cancer with four treatment options: surgery+postoperative chemotherapy, surgery+ postoperative chemotherapy+radiofrequency ablation. According to the inclusion criteria and exclusion criteria, the literature was screened and data were extracted. The quality of the literature was evaluated using Jadad tools, and stata was used. Net⁃like meta⁃analysis was performed with GeMTC software, and the publication bias was evaluated by funnel plot method, Begg′s Test and Egger′s Test, and the evaluation of heterogeneity among the included correlations was tested by Q test and I2 index. Results A total of 10 studies, 4 treatments, and 1026 subjects were included. The results of the net⁃like meta⁃analysis showed that the number of patients who survived the first year, the third year, and the fifth year after the treatment of preoperative chemotherapy+ surgery+postoperative chemotherapy was the highest among the four treatment options. Conclusion In the evaluation of the number of survivors, the clinical effects of preoperative chemotherapy+surgery+postoperative chemotherapy are better than the other three treatment options.