Tumor metabolism is characterized by aerobic glycolysis with metabolic disorder of amino acid and lipid, which is the solid foundation of tumorigenesis. The special metabolic pattern can not only support the rapid growth of cancer, but also benefit tumor from the hypoxia and acidic surrounding environment, contributing to induce gene mutation, promote proliferation and metastasis and suppress immunity, which provides a proper condition to tumor development.Tumor metabolism becomes recent hotspot in research correspondingly. Blood stasis is a common syndrome of traditional Chinese medicine among advanced cancer patients. The pathological mechanism of blood stasis is similar to metabolic disorder. Thus, the mechanism of activating blood circulation in treating cancer was considered to be related to regulate tumor metabolism. Researches report that Chinese medicine for activating blood circulation could regulate the activities of metabolic enzymes and metabolic pathway⁃related proteins, affect mitochondrial function, reduce the intake of nutrients such as glucose in cancer cells, inhibit aerobic glycolysis, reduce lactic acid production, change the hypoxic environment of tumors, and inhibit angiogenesis, which provide evidence for the mechanism of Chinese medicine for activating blood circulation regulating tumor metabolism. In this paper, the mechanism of traditional Chinese medicine activating blood drugs in treating tumor was reviewed and discussed via regulating tumor metabolism, which contributes to elucidating the anti⁃tumor mechanism of activating blood drugs, provides a new direction for the further research and guide the application of Chinese medicine for activating blood circulation in tumor treatment.