Objective To explore the relationship between preoperative M stage and clinical features and prognosis of colorectal cancer patients in order to provide theoretical basis for the prevention and clinical treatment. Methods The study is a retrospective cohort study. From August 2011 to August 2014 cases of colorectal cancer which confirmed by surgery and pathology were selected from the hospital.We collected the clinical data and follow⁃up of patients until patients died, lost to follow⁃up or to the deadline.The deadline is August 31, 2019. Results A total of 147 patients were included in this study. They were divided into 2 groups according to TNM stage, including 106 patients in stage M0 group and 41 patients in Stage M1 group. Compared with M0 group, the incidence of biliary tract disease, appendiceal disease and liver metastasis were higher in M1 Group (P<0.05).The age of onset was different in the two groups. M0 group aged 60-79 years and 80-99 years accounting for the majority, while M1 group aged 20-39 years and 40-59 years accounting for the majority. Conclusion As an independent prognostic factor for patients with colorectal cancer, preoperative M stage is an important prognostic indicator for predicting the prognosis of patients with colorectal cancer, while the history of biliary tract, history of appendix and liver metastasis are related to the postoperative prognosis of patients with colorectal cancer.