With the wide application of enteral nutrition in clinic, the incidence of adverse reactions of enteral nutrition is gradually increasing. In order to improve the understanding of the related clinical personnel on the adverse reactions of enteral nutrition, improve the quality of nutrition treatment, reduce the adverse reactions caused by improper use, and ensure the effectiveness and safety of patients using enteral nutrition, objective to provide scientific basis for the standardized management of enteral nutrition for relevant medical staff. The related factors influencing the clinical outcome of enteral nutrition were extracted as the indicators of monitoring the clinical adverse reactions of enteral nutrition. The classification and preventive measures of enteral nutrition adverse reactions are summarized as follows. The types of enteral nutrition adverse reactions can be divided into sensory adverse reactions, gastrointestinal adverse reactions, allergic reactions and metabolic complications. Gastrointestinal malnutrition can be monitored through monitoring indicators such as taste discomfort, nausea, vomiting, abdominal distension, diarrhea, gastric retention, allergy, hyperosmolar dehydration, abnormal blood glucose, electrolyte abnormalities, and trace elements. In case of adverse reactions caused by enteral nutrition, we need to adjust the way of nutritional support treatment, adjust the feeding temperature, change the bolus to gravity drip or pump, and use the heater; Adjust the way of feeding and use pre digestion or short peptide preparation; adjust the dosage and concentration of enteral nutrition, from less to more, from thin to thick, reduce osmotic pressure, and gradually increase the feeding dose to relieve the symptoms of enteral nutrition intolerance, improve the nutritional level of patients, and prevent the occurrence of enteral nutrition adverse reactions.