Objective To explore the effects of the implementation of the goal⁃directed nutrition on the nutritional status and postoperative rehabilitation of operative patients with liver cancer combined with cirrhosis from admission to discharge. Methods A cancer target nutrition team was established, a target nutrition pathway implementation list was formulated and applied throughout the whole progress of hospitalization, pre⁃operation, post⁃operation, discharge from hospital, and post⁃discharge.121 liver cancer patients operated before the implementation of goal⁃directed nutrition pathway management were included in the control group, and 126 patients operated after implementation were selected as the trial group. We evaluated the efficacy of intestinal nutrition efficacy real⁃timely and dynamically regulated the target nutrition in the experimental group. The changes of some data such as skeletal muscle, albumin, prealbumin on the 14th day after surgery, and the recovery time of intestinal function, postoperative complications, and the average hospital stay were compared between the two group. Results In the experimental group, there were no significant decrease in the skeletal muscle, the recovery time of intestinal function was significantly earlier, the level of albumin and prealbuminon was significantly better than that of the control group, and the incidence of bloating, diarrhea, ascites and infection was significantly lower than that of the control group. Conclusion The target nutrition management in the perioperative period delivered by the nutrition support group is a feasible nutrition implementation management mode for liver cancer patients, which can improve the nutritional status of patients and promote the rehabilitation of patients after surgery.