Oral nutritional supplements is the preferred nutritional therapy for patients with malnutrition or nutritional risk without enteral nutrition contraindications. Patient compliance is the key factor affecting the implementation of oral nutritional supplements. Improving compliance to oral nutritional supplements is of great significance to achieve the goal of nutritional treatment and promote the nutritional status of patients. But due to various factors derived from patients, medical institutions, supplements, and other aspects, patients′ compliance to oral nutritional supplements is poor. The clinical practice of using oral nutritional supplements should be further standardized from the following aspects：① the best team building for nutrition therapy;② patient evaluation before oral nutritional supplements therapy; ③ health education for patients with oral nutritional supplements; ④ prevention and management of intolerance to oral nutrition supplements; ⑤ management of symptoms or diseases that affect nutrient intake; ⑥ improvement of patients′ acceptance of supplements; ⑦ follow⁃up and monitoring of patients, to improve patient′s compliance to oral nutritional supplements.