Parenteral nutrition (PN) serves as an important therapeutic modality in all clinical departments, which can improve the nutritional intake and nutritional status of patients, and improve the clinical outcome of patients. PN is one of the most risky forms of medication. That is used for a variety of indications, has diverse prescription components and infusion approaches. There are many differences between doctors of different specialties in the grasp of indications, prescription components, infusion route selection and other aspects, which may lead to safety PN problems, even to death. To improve the safety of parenteral nutrition for Chinese clinicians and maximize the clinical benefits of parenteral nutrition. Chinese Society of Nutritional Oncology, Chinese Society of Parenteral and Enteral Nutrition organized experts to formulate this consensus. This consensus according to Chinese nutrition diagnosis and treatment status, published evidence, combined with clinical, pharmaceutical, nutrition, nursing and other fields of expertise. These consensus recommendations are based on practices and Oxford Center for Evidence⁃based Medicine (OCEBM) grading standards that are generally accepted to minimize errors with PN therapy, categorized in the areas of PN prescribing, compounding, infusion route selection, and complications administration.