Objective To investigate the nutritional status of patients with common digestive tract cancer and analyze the correlation between nutritional status and tumor characteristic factors and blood inflammatory indicators.Methods Clinical data of 298 patients with esophageal cancer, gastric cancer and colorectal cancer in our hospital from January 2019 to December 2020 were collected.According to the PG⁃SGA score, the patients were divided into three groups: no or mild malnutrition, moderate malnutrition and severe malnutrition, and the differences in related clinical characteristics, blood and inflammatory indicators among the three groups were compared. Results Among the 298 patients, no or mild malnutrition accounted for 34.2%, moderate malnutrition accounted for 26.5% and severe malnutrition accounted for 39.3%.There were no significant differences in age, gender, degree of tumor differentiation and blood lipid levels among the three groups (P>0.05).Patients in stage Ⅲ-Ⅳ were more likely to suffer from moderate or severe malnutrition than those in stage Ⅰ-Ⅱ.In the severe malnutrition group, the proportions of esophageal cancer, gastric cancer and colorectal cancer were 41.0% vs 36.8% vs 22.2%, respectively, P<0.05.Patients with severe malnutrition had lower levels of BMI, HB, LY, TP, and PAB.And they were more likely to have hypoproteinemia, high platelet count, and elevated D⁃dimer levels.The results also showed that the proportion of WBC, CRP, IL⁃6 and NLR in peripheral blood increased with the increase of malnutrition degree, which were 1.9% vs 7.6% vs 14.5%, 29.4% vs 51.9% vs 61.5%, 15.7% vs 27.8% vs 53.0% and 35.3% vs 38.0% vs 70.9%, respectively, with significant differences (P<0.05).The proportion of PLR increased in severe malnutrition group was more than 50% (P<0.05).The optimum cut⁃offs of IL⁃6, NLR and PLR were 4.75, 2.47 and 150.5 for moderate or severe malnutrition.Conclusion Patients with digestive tract cancer are prone to moderate or severe malnutrition. The clinical stages and inflammatory indicators are correlated with nutritional status to a certain extent, and have suggestive value in clinical application to guide early intervention.