Objective To analyze the evaluation value of preoperative albumin/globulin ratio (A/G) and prognosis nutrition index (PNI) for the prognosis in patients with endometrial carcinoma (EC) after operation. Methods 101 patients with EC admitted into our hospital from March 2016 to March 2018 were reviewed. The patients were treated with radical resection and radiochemotherapy after operation. The follow⁃up time was 38⁃60 months and the median time was 50.5 months. According to receiver operating curve (ROC curve), the area under curve (AUC) and optimal cut⁃off value of preoperative serum A/G and PNI for predicting and overall survival rate were obtained. They were divided into low A/G group (<1.5, n=58) and high A/G group (≥1.5,n=43), low PNI group (< 45.0,n=62)and high PNI group (≥45.0,n=39). The relationship between A/G, PNI and EC clinical data (including age, body mass index, tumor diameter, FIGO stage, pathological classification and differentiation grade, treatment mode, myometric infiltration depth and lymphatic vascular space infiltration) were analyzed, and independent predictors of progression free survival rate and overall survival rate were screen. Results ROC showed that the AUC values of A/G and PNI for overall survival rate were 0.802 and 0.856, respectively (P<0.05),Youden index were 0.742 and 0.739. The age, FIGO stage, myometric infiltration depth and lymph vessel space infiltration in low A/G group were higher than high A/G group,FIGO stage, myometric infiltration depth, lymph vessel space infiltration, low differentiation and radiochemotherapy in low PNI group were higher than high PNI group(P<0.05). The univariate Cox regression analysis showed that age, FIGO stage, myometric invasion depth, lymph vessel space infiltration, differentiation grade, treatment mode,serum A/G and PNI were risk factors of progression free survival rate and overall survival rate(P<0.05). The multivariate Cox regression analysis showed that age≥65 years, FIGO stage Ⅲ~Ⅳ, myometric infiltration depth ≥ 1/2, lymph vessel space infiltration, A/G < 1.5 and PNI < 45.0 were independent risk factors of progression free survival rate and overall survival rate (P<0.05). The Kalpan⁃Meier curve showed that progression free survival rate and overall survival rate in low A/G group were significantly lower than high A/G group,low PNI group were significantly lower than high PNI group(P<0.05). Conclusion Lower serum A/G and PNI are of great value for predicting the adverse outcome of progression free survival rate and overall survival rate in EC patients. A/G < 1.5 and PNI < 45.0 can be used as important references for early evaluation of worse prognosis in EC patients.