Objective To analyze the application value of serum fibrinogen/albumin ratio (FAR) combined with prognostic nutrition index (PNI) in predicting prognosis of patients with resectable gastric cancer after radical operation, and screen simple biochemical indicator with higher sensitivity and accuracy. Methods A retrospective summary of a total of 155 patients with resectable gastric cancer who were admitted to the Ganyu District People’s Hospital in Lianyungang City from October 2017 to October 2020. The follow⁃up was 3.0⁃38.0 months after radical operation, and the median time was 27.5 months. The AUC and optimal cut⁃off values of the baseline serum FAR and PNI were obtained by receiver operator characteristic curve（ROC curve）as the basis of grouping, then the clinical data, biochemical indicators and cumulative total survival rate of the patients were compared, the risk factors were screened by univariate and multivariate Cox regression analysis. Results There were up to 64 patients of death during the follow⁃up, with a mortality rate of 41.3% (64/155).ROC curve analysis showed that the AUC values for predicting the total death by FAR and PNI were 0.798 and 0.812, the cut⁃off were 0.112 and 41.52 respectively, and the AUC value of FAR combining with PNI was 0.865, higher than FAR or PNI (P<0.05). 155 patients were divided into three groups, 60 patients in group A (FAR≥0.112 and PNI≥41.52), 45 patients in group B (FAR≥0.112 and PNI<41.52, or FAR<0.112 and PNI≥41.52), 50 patients in group C (FAR<0.112 and PNI<41.52),there were significant differences of patients’age, tumor diameter, TNM stage, T stage and N stage among the three groups (P<0.05).Kaplan⁃Meier curve showed that one⁃year and three⁃year cumulative survival rates of group C were lower than group A and group B (P<0.05). The univariate and multivariate Cox regression analysis showed that age (≥60 years), TNM stage (stage Ⅲ),FAR (<0.112)and PNI (<41.52) were independent risk factors to death (P<0.05). Conclusion The decreases of FAR and PNI values before operation may indicate poor prognosis in patients with resectable gastric cancer, combined with FAR and PNI can be used as important biochemical indicator to evaluating the prognosis of patients, which has a good predictive effect.