Cytoglobin（GYGB）, a stellate cell⁃specific globin, has recently become a hotspot protein due to its association with liver fibrosis. The control of inflammation in tumor occurrence and development plays a quite important role in the process, and the transformation of“inflammation⁃cancer”mechanism research in the field of cancer basic research has become a new frontier, and the transformation of“inflammation⁃cancer”regulation network, molecular mechanism and signal pathway has gradually become the main target of tumor prevention and treatment. This review mainly summarizes the potential functions of globulin in the liver, including oxidative stress and signaling pathway transduction, and further discusses the inhibition of CYGB in the transformation from non⁃alcoholic steatohepatitis to primary liver cancer in three aspects: inactivation of hepatic stellate cells, increase of fat transport and resistance to oxidative stress. The study of“inflammation⁃cancer”transformation will provide a new breakthrough for the prevention, diagnosis and treatment of primary liver cancer.