Lipids include fats (triglycerides) and lipids (phospholipids and sterols). Lipids provide essential fatty acids and energy for the body. Lipid metabolism disorder is considered to be the metabolic feature of many malignant tumors, including colorectal cancer. Abnormal lipid metabolism will lead to changes in cell membrane structure, abnormal cell signal transduction, imbalance of energy homeostasis, destruction of gene expression and protein distribution, which will affect a series of cell functions such as cell proliferation, differentiation, metabolism, apoptosis and information transmission. Studies have shown that abnormal lipid metabolism is closely related to the occurrence and development of colorectal cancer. High level of fatty acid metabolism is one of the most abnormal metabolic changes of tumor cells. Some lipid metabolic pathways may become potential specific targets for the treatment of colorectal cancer. The relationship between lipid metabolism and the occurrence and development of colorectal cancer, as well as their interaction, is one of the hot spots of tumor nutrition and metabolism. At present, the research results are still controversial and need to be further confirmed by more clinical and basic studies. This paper will systematically elaborate the relationship between lipid metabolism and the occurrence and development of colorectal cancer from three aspects of fatty acid, triglyceride and cholesterol, and inspire the cellular signal and molecular mechanism of interfering with its metabolic pathway, which may provide a new direction for the treatment of colorectal cancer.