Pancreatic cancer is a highly malignant wasting disease, 80％- 90％of pancreatic cancer patients experience emaciation, fatigue, and weight loss in the early stages of the disease. Advanced neoplasms are associated with poor fluid mass and may present with electrolyte disturbances, hypoproteinemia, and changes in blood glucose. Patients with pancreatic cancer need routine nutritional screening and evaluation, and actively give nutritional treatments. Principles of nutritional therapy for pancreatic cancer: ① Enteral nutrition is the first choice for patients with malnutrition and normal gastrointestinal function.②Postoperative nutrition treatment can be given according to the concept of accelerated rehabilitation surgery to help patients enter the next stage of treatment.③ Nutritional therapy is recommended for pancreatic cancer patients with stable vital signs and autonomic eating disorder who have received radiotherapy and chemotherapy. In principle, systemic nutritional therapy should not be considered for patients with unstable vital signs and multiple organ failure.④ Patients with obstruction and pancreatic cancer who cannot eat orally need parenteral nutrition.