Cholesterol is an indispensable component of the structure of cell membranes in the human body, involved in regulating the biophysical properties of cell membranes, and is also a precursor to the synthesis of bioactive molecules such as bile acids, sterol hormones, and oxysterols. Maintaining the metabolic balance of cholesterol is essential for maintaining the life activities of cells and the body. Imbalance of cholesterol metabolism in the human body is a risk factor for many diseases such as atherosclerosis, gallbladder stones, cholestatic liver damage, hypercholesterolemia, myocardial infarction, etc., and plays an important role in the occurrence and development of a variety of tumors. lncRNA does not code for protein, which regulates transcription, translation, mRNA cleavage, post⁃transcriptional modification and other processes to exert its biological effects such as regulating epigenetics, controlling the cell cycle, regulating differentiation and immune response. lncRNA is an important epigenetic regulator in gene expression, in recent years, with the maturity of sequencing and gene chip technology, more and more studies have confirmed the interaction between lncRNA and its regulated protein⁃coding genes, forming a highly complex regulatory network, participating in a variety of life activities and disease progression, and the mutation or expression abnormality of lncRNA has a regulatory effect on the occurrence and development of many diseases. lncRNA has been found to play an important regulatory role in human cholesterol metabolism through a variety of pathways. In this paper, the research progress of lncRNA regulation of cholesterol metabolism and cholesterol metabolism⁃related diseases is reviewed.