CAR-T cell therapy is a cutting-edge effective and rapidly evolving adoptive cell immunotherapy that recognizes tumor cell surface antigens independently of major histocompatibility complexes thereby reducing immune escape due to loss of tumor cell MHC-associated antigen presentation. Although it has been applied in blood cancer and made remarkable achievements its application in solid tumors is still affected by some adverse factors. Metabolism is one of the detrimental factors a set of basic cellular processes that not only sustain cell survival and proliferation but also serve as a means for cells to adapt to their local environment. Massive competition for nutrients such as carbohydrates and amino acids generated by tumor cell metabolism in the tumor microenvironment coupled with immunosuppression leads to mitochondrial dysfunction failure and subsequent CAR-T cell depletion leading to failure of CAR-T cell therapy. Elucidating cellular intrinsic and extrinsic factors that inhibit CAR-T cell function in solid tumors will facilitate the development of immunotherapy to establish a more durable and effective response in patients. In this review we briefly review the application of tumor metabolism-related immunosuppressive factors in CAR-T cell therapy as well as recent advances and strategies to improve the metabolic adaptability and antitumor activity of CAR-T cells in vivo and in vitro.