Objective To explore the application effect of whole course comprehensive nutrition management in elderly patients with liver cancer after drug-eluting beads transcatheter aterial chemoembolization DEB-TACE . Method Taking the elderly patients with liver cancer who underwent DEB-TACE in the Department of hepatobiliary surgery and geriatrics of our hospital from April 2019 to April 2021 as the research object 48 cases in the control group from April 2019 to April 2020 before the implementation of the whole process comprehensive nutrition management 56 cases in the experimental group from May 2020 to April 2021 after the implementation of the whole process comprehensive nutrition management 4 cases in the control group and 6 cases in the experimental group. The control group received routine nutritional treatment after liver cancer embolization and the experimental group adopted the whole process nutritional comprehensive management mode. The patients􀆳 body mass index NRS 2002 score nutritional index feeding standard rate complication rate and quality of life were observed at admission 7 days and 1 month after operation. Result The BMI feeding standard rate gastrointestinal complications metabolic complications physiological and functional status of quality of life in the experimental group were better than those in the control group and the difference was statistically significant P< 0. 05 There was no significant difference in NRS 2002 score hemoglobin albumin total protein mechanical complications social and family status and functional status in quality of life P>0. 05 There were significant differences in BMI albumin total protein and physiological status one month after operation compared with those at admission and seven days after operation P< 0. 05 . Conclusion The whole course comprehensive nutrition management can improve the nutritional status of elderly patients with liver cancer after drug loaded microspheres embolization over time so as to improve the quality of life of patients