Objective To explore the application value of nutrition management during radiotherapy and chemotherapy for esophageal cancer in multiple disciplinary team by the nutrition management system. Method Between January and December 2020 101 patients with esophageal cancer in the Department of Radiotherapy at Affiliated Hospital of Nantong University were selected. They were randomly divided into control group with 50 patients and intervention group with 51 patients according to the random number method. The control group was given conventional treatment and nursing. The study group established a nurse - led multiple disciplinary team based on the nutrition management system built 􀆵Admission assessment—results evaluation—nutrition intervention—treatment monitoring—nutrition tracking nutrition management process. Clinical nutritional indicators Clinical outcomes were compared between the two groups and cost-effectiveness ratio was conducted. Result The changes of lymphocyte count total protein albumin prealbumin in the intervention group were significantly lower than those in the control group P<0. 05 . The incidence of radiation-related complications in the intervention group was significantly lower than those in the control group P<0. 05 . FACT-G score in the intervention group was significantly higher than those in the control group P<0. 05 ECOG score in the intervention group was significantly lower than those in the control group P<0. 05 . The hospitalization expenses per capita in the intervention group were significantly lower than those in the control group P<0. 05 . C/ E of clinical response rate were 262. 7 and 498. 6 and C/ E of functional assessment were 245. 5 and 353. 9 in 2 groups C/ E in the intervention group ware lower than those in the control group. Conclusion Nutrition management during radiotherapy and chemotherapy for esophageal cancer in multiple disciplinary team by the nutrition management system can significantly improve the patient􀆳s nutritional status and quality of life reduce the hospitalization expenses decrease the incidence of related complications. It has good cost-effectiveness ratio and economic value.