Objective To analyze the effects of vitamin B2 combined with Kangfuxin Solution on oral mucositis and nutritional status of patients with head and neck cancer after radiotherapy. Method A total of 108 patients with head and neck cancer diagnosis into our hospital from January 2020 to January 2022 were prospectively enrolled. They were all treated with intensity-modulated radiotherapy the total treatment dose was 60 ~ 74 Gy once a day five times a week for 6 ~ 7 weeks It can be combined with chemotherapy at the same time. All patients had oral mucositis then they were randomly divided into control group and observation group with 54 cases in each group. The control group only took vitamin B2 orally and the observation group combined with vitamin B2 and Kangfuxin solution. The severity of oral mucositis grade Ⅲ/ Ⅳ was assessed according to the Radiation Therapy Oncology Group RTOG standard the degree of pain was assessed by visual analogue scale VAS . Nutritional indicators included weight loss body mass index BMI loss albumin loss prealbumin loss hemoglobin loss and total lymphocyte count loss as well as Patient Generated – Subjective Global Assessment PG-SGA score adverse reactions included dry mouth nausea and vomiting thrombocytopenia neutropenia neurotoxicity and nephrotoxicity. Result The incidence of grade Ⅲ/ Ⅳ oral mucositis in the observation group was significantly lower than that in control group the disappearance time of oral mucositis was shorter than control group too P < 0. 05 . The pain VAS scores of the two groups at 2h 4hand 6h after treatment were lower than before treatment and they in the observation group was furtherly less than control group P < 0. 05 . The weight loss and BMI loss at 4 and 7 weeks after treatment albumin loss at 7 weeks after treatment in the observation group were significantly lower than those in control group P < 0. 05 . The PG-SGA score of the observation group 7 weeks after treatment showed that the nutritional status was better than control group P < 0. 05 . There was no difference of the incidence of adverse reactions between the two groups P > 0. 05 . Conclusion Vitamin B2 combined with Kangfuxin Solution can greatly improve the oral mucositis and nutritional status of patients with head and neck cancer after radiotherapy reduce pain which has a good clinical value.