Objective To explore the effect of home enteral nutrition combined with probiotics on nutritional status and cancer-related fatigue in patients with esophageal cancer after radiotherapy. Method 80 patients with esophageal cancer who received radiotherapy in the inpatient department of our hospital from January 2019 to September 2020 were selected as the research objects. According to the random number table method the 80 patients were divided into the experimental group and the control group with 40 cases in each group. The group received home enteral nutrition combined with probiotics while the control group received only routine enteral nutrition support. The nutritional index intestinal flora cancer-related fatigue and complications of the two groups were observed. Result After treatment the nutritional indexes of serum albumin hemoglobin prealbumin transferrin triceps skinfold thickness and upper arm muscle circumference in the experimental group were higher than those in the control group P<0. 05 the number of Bifidobacterium Lactobacillus Clostridium perfringens Enterobacter Enterococcus and Bacteroides in the experimental group were significantly higher than those in the control group P<0. 05 . The number of fatigue patients in the experimental group was significantly lower than that in the control group P<0. 05 . The incidence of pulmonary urinary system wound or catheter infection complications in the experimental group was lower than that in the control group P<0. 05 . Conclusion Home enteral nutrition combined with probiotics can improve the nutritional level of patients with esophageal cancer after radiotherapy which is beneficial to the recovery of intestinal flora and does not increase the discomfort of patients. Quality has far-reaching significance and it is worth exploring some influences in depth.