Triple-negative breast cancer is a subtype of breast cancer that lacks the expression of estrogen receptor progesterone receptor and human epidermal growth factor receptor 2. Its clinical characteristics are high degree of deterioration easy recurrence high metastasis rate and low survival rate. This kind of breast cancer accounts for 15% - 20% of all breast cancer cases and the treatment lacks effective targets. Metabolic abnormality is one of the important characteristics of tumor diseases. Therefore analyzing the characteristics of triple-negative breast cancer from metabolic pathway is a new direction of personalized nutritional therapy. Recent studies have found that the metabolism of nutrients especially amino acids in triple-negative breast cancer cells is different from normal cells and is also different from other subtypes of breast cancer cells. This paper reviews the characteristics of amino acid metabolism and related regulatory mechanisms in triple-negative breast cancer cells. It is found that the levels of glutamate / glutamine cystine / cysteine methionine glycine serine and tryptophan are different from normal cells or other types of tumor cells and the transformation and transport of amino acids are also in an abnormal regulatory state. Based on this characteristic regulating the corresponding metabolic pathway by limiting the target amino acids may have a good effect on the treatment of triple-negative breast cancer. At present nutrition deprivation has become an adjuvant treatment strategy for cancer cells. The in - depth study of the metabolic characteristics of the disease is of great significance for finding the target of nutrition therapy.