The number of cancer cases and deaths in the world is still increasing year by year which seriously threatens human health and life resulting in a huge disease burden. The trend is particularly acute in China with a large aging population. The prevention and treatment of cancer have been included in the national health policy outline and the national nutrition plan. The occurrence and development of tumors are the result of the interaction of genetic factors and environmental factors. Emerging evidence has been proven that nutrition plays an important role in the prevention and treatment of cancer. The development direction of precision nutrition is to abandon the " one -size -fits -all" nutrition approach and divide the population into different subgroups according to lifestyle dietary and environmental exposure genetics microbiology metabolomic and biomarkers so as to form more scientific and reasonable dietary recommendations or nutritional intervention strategies. The occurrence and development of tumors are often accompanied by nutritional imbalance and metabolic disorder. Therefore this review focuses on the relationship between tumor and nutrition and discusses the research progress and development direction of tumor and nutrition metabolomic including one-carbon metabolism and folate-regulated metabolism . In the future we hope to establish comprehensive life-cycle management standards and guidelines for cancer and precision nutrition that are more suitable for the Chinese population and ultimately reduce the incidence and disease burden of cancer improve the health level and enhance the quality of life and treatment outcome of cancer patients.