Objective To explore the effect of a novel enteral nutrition formula fortified with L-carnitine and taurine on patients undergoing chemotherapy for lung cancer to provide clinical practice basis for the development of a novel nutrition formula. Method Lung cancer patients who were admitted to Banan Hospital Affiliated to Chongqing Medical University from May 2021 to June 2022 were screened and randomly divided into two groups. The experimental group was given by a novel enteral nutrition formula supplemented with L-carnitine and taurine and the control group was given by a conventional whole protein enteral nutrition formula. The patients took 50 g of their own formula three times a day for 12 weeks. The quality of their daily life nutritional status and the incidence of toxic and side effects during chemotherapy were compared between the two groups pre- and post- treatment. Result A total of 83 patients were involved in the experimental group and 85 patients were involved in the control group. Before treatment there was no significant statistical difference between the two groups in the scores of quality of life in various fields including body mass index total serum protein albumin hemoglobin and subjective overall nutrition assessment scale P>0. 05 . After treatment the patients in the experimental group obtained higher scores in all fields of quality of life. Especially body mass index total serum protein albumin and hemoglobin were significantly higher than those in the control group. Even the lower all subjective nutrition assessment scale score was the better nutritional status is. The difference was statistically significant P<0. 05 . The grade of leukocyte toxicity and side effects in the experimental group were lower than those in the control group the gastrointestinal reaction was smaller and the duration of malignant vomiting was shorter than that in the control group. The difference was statistically significant P<0. 05 . Conclusion The novel enteral nutrition formula strengthened with L-carnitine and taurine can be applied to lung cancer chemotherapy patients which is conducive to improving their quality of life and their nutritional status and reducing the toxic and side effects of chemotherapy.