The incidence of breast cancer has shown a staggering trend in different regions globally. In terms of the rate of increase in incidence and mortality developing countries represented by China show an increasing trend while in highly developed countries like the United States there is an overall decreasing trend. We aim to illustrate the difference in incidence mortality survival rate and treatment between China and the United States through a systematical comparison and analysis. The results show that China has lower mortality in breast cancer than the United States though a higher proportion of the global incidence. China is far from a standard breast cancer screening procedure which leads to a ten-year delay in diagnosis of breast cancer in Chinese women than in American women accompanied by the advanced stage of cancer and larger tumor sizes. Chinese women are diagnosed at a more advanced stage and with larger tumors. This determines the different tendencies of the two countries regarding the prevention and treatment of breast cancer. In conclusion the successful experience of dealing with breast cancer in America shed a light on China to escape from the health public burden resulted from the occurring new cases.