Objective To observe the effect of probiotics combined with enteral nutrition support on postoperative inflammatory factors cellular immune function and nutritional indicators in patients with gastric cancer after radical operation. Method 134 patients with gastric cancer who underwent laparoscopic assisted radical gastrectomy in general surgery department of Department of General Surgery Zigong First People's Hospital from January 2020 to July 2022 were selected and randomly divided into control group n = 67 and observation group n = 67 The control group received early enteral nutrition support EENS group and the observation group received probiotics combined with early enteral nutrition support PEENS group. The levels of inflammatory factors IL-2 IL-6 TNF - α cellular immune function CD4 + CD8 + CD4 + / CD8 + and nutritional indexes albumin and total protein levels in peripheral blood measured by protein analyzer and complications were compared between the two groups before and after treatment. Result After the intervention the levels of IL-2 IL-6 and TNF - α in the observation group were significantly lower than those in the control group and before the intervention P<0. 05 + / CD8 + levels were significantly higher than those in the control group and before intervention P<0. 05 CD8 + levels in the observation group after intervention were significantly lower than those in the control group and before intervention P < 0. 05 albumin and total protein levels in the observation group after intervention were significantly higher than those in the control group and before intervention P < 0. 05 there was no significant difference in the incidence of complications between the two groups P>0. 05 . Conclusion Probiotics can effectively reduce the level of inflammatory response protect cellular immune function and improve nutritional status in patients with early gastric cancer after operation.