High-dose vitamin C HVC therapy is a safe and inexpensive anticancer treatment which could cure cancers by promoting oxidative stress epigenetic modification inhibiting HIF-α and immune regulation. However clinical practice has shown that there is only a "weak" inhibitory effect on cancers in high-dose vitamin C application alone. Moreover the anticancer effect of high-dose vitamin C is closely related to the metabolic phenotype. Cancers with mutations in KRS / BRAF HIF TETs/ IDH/ WT1 and high expression of OMM Cyb5R3 / VDAC1 complex or vitamin C transporters are sensitive to HVC treatment. However high -dose vitamin C had no obvious inhibitory effect on tumors with low KRS / BRAF expression suggesting that high-dose vitamin C should be targeted at tumor metabolic phenotype for precise treatment. On the other hand some preclinical trials have shown that there are some methods could improve the anticancer efficacy such as HVC combined with other kinds of vitamin vitamin C nano-crystallization oncolytic virus programmed death receptor - 1 / programmed death ligand - 1 monoclonal antibody and other immune checkpoint inhibitors radiotherapy cytotoxic drug therapy or traditional Chinese medicine etc. It is suggested that precise intensive therapy is an important research direction of high dose vitamin C therapy for tumor but more clinical evidence is still needed.