High-dose intravenous vitamin C HVC has the advantages of low toxicity and low cost and can be combined with other treatments as an emerging treatment strategy for anti - tumor. Its anti - tumor mechanism is mainly pro - oxidative stress. HVC can produce hydrogen peroxide H2O2 produce hydroxyl radicals OH· by Fenton reaction with Fe 2+ and dehydroascorbic acid DHA reduction to kill tumor cells. It can also affect epigenetic regulation and oxygen regulation through the regulation of enzyme activity by redox-active metal particles. In addition HVC can play a role by enhancing immune function and inhibiting tumor metastasis and invasion. A large number of preclinical have shown that HVC can increase the therapeutic effect and reduce the treatment-related adverse reactions. Kirsten rats arcomaviral oncogene homolog KRAS and v-raf murine sarcoma viral oncogene homolog B1 BRAF mutations ten-eleven translocation TET enzymes etc. may be potential therapeutic targets. At present the clinical studies of HVC combined therapy include colorectal cancer gastric cancer pancreatic cancer lung cancer ovarian cancer hematological tumors etc. confirming that HVC combined therapy is safe and has a certain anti-tumor effect. However most of the current studies are single-center and small-sample studies. In the future large-sample prospective randomized controlled trials are still needed and further explore the anti-tumor mechanism of HVC to screen out treatment-sensitive markers.