Objective Research β-hydroxy-β-methylbutyrate HMB on muscle quality and nutritional status of patients with liver cirrhosis. Method The patients with cirrhosis who met the inclusion criteria were selected from August 2021 to August 2022. They were randomly divided into control group n = 30 and test group n = 30 . Both groups were given routine treatment such as liver protection enzyme lowering and nutritional treatment. On the basis of the treatment in the control group the experimental group was treated with oral nutritional supplements rich in HMB . The body weight albumin grip strength skeletal muscle index SMI triceps skinfold thickness TSF arm muscle circumference AMC liver function Child-Pugh grade and Barthel index score of the two groups were compared at three time points 0 3 and 6 weeks . Result The body weight and SMI albumin of patients in the test group were significantly increased and the difference between the two groups was statistically significant P<0. 05 . TSF and AMC decreased in both groups However there was no significant difference between the two groups P>0. 05 . There was no significant difference in Child-Pugh liver function grading and Barthel index between the two groups P>0. 05 . Conclusion Myopenia is more common in patients with liver cirrhosis due to the damage of metabolism and synthesis. This study found that HMB nutrition can improve the function of skeletal muscle and the nutritional status of the body to a certain extent through the intervention of liver cirrhosis patients Inhibit the decomposition of muscle and protein increase the muscle quality of patients but do not improve the damage degree of liver function and personal self-care ability.