Colorectal cancer CRC is a common malignant tumor of the digestive system and its occurrence and development are not only related to the characteristics of tumor cells themselves but also closely related to the tumor microenvironment TME . As an important component of TME tumor-associated macrophages TAMs regulate a variety of key oncogenic processes in CRC promote tumor genesis proliferation and metastasis by secreting cytokines and chemokines and coordinating with inflammatory mechanisms. Based on the impact of TAMs on tumor progression the current therapeutic strategies targeting tumor macrophages mainly focus on TAMs as targets for immunotherapy inhibition of macrophage recruitment reinduction of phenotypic polarization of TAMs and combination of TAMs targeted therapy with conventional treatment. Therefore the growing understanding of the functional and regulatory mechanisms of TAMs will allow us to effectively explore their clinical application in colorectal cancer. In this review we describe the role and related mechanisms of TAMs in the occurrence and progression of colorectal cancer and based on the above summarize the potential therapeutic strategies for colorectal cancer related to TAMs so as to provide emerging treatment ideas and methods for the diagnosis and treatment of CRC which has effective reference value.