Objective This study aimed to investigate the relationship between cumulative Triglyceride - glucose index cumTyG index and the risk of colorectal cancer CRC . Method Criteria for selecting the subjects were as follows A total of 68 902 in-service and retired employees of Kailuan Group who had attended at three consecutive physical examinations in 2006- 2007 2008- 2009 2010-2011 and 2012-2013. According to the thirdtile of cumulative TyG the participants were divided into three groups namely cumulative TyG1 cumTyG1 cumulative TyG2 cumTyG2 and cumulative TyG3 cumTyG3 . CRC was the primary endpoint. Kaplan-Meier curve was used to calculate the cumulative incidence of CRC in different cumulative TyG groups and log-rank test was used to compare the differences among groups. Cox proportional risk model was used to analyze the impact of different cumTyG and used to exclude people taking hypoglycemic drugs lipid-lowering drugs and CRC events within one year on CRC. C-index and time-dependent receiver operating characteristic curve time - roc were used to assess the diagnostic efficacy of cumTyG index exposure and single-measured TyG index exposure on CRC. Result At average follow-up 10. 13±1. 95 years the incidence density of cumTyG1~ cumTyG3 group was 4. 23 5. 56 and 6. 90 per 10 000 person-years respectively and with the increase of cumTyG exposure level the cumulative incidence of CRC also showed an increasing trend and the difference was statistically significant by og-rank test χ2 = 15. 31 P<0. 001 . Cox proportional hazards model showed that after adjusting for potential confounding factors the HR 95% CI of CRC in the cumTyG2 and cumTyG3 groups were 1. 20 0. 91 1. 57 and 1. 36 1. 03 1. 81 compared with the cumTyG1 group. People taking hypoglycemic drugs lipid-lowering drugs and CRC within 1 year were excluded Cox proportional hazards models and adjusting for potential confounding factors were repeated and the results showed that the risk of CRC in the three groups was increased by 34% HR= 1. 34 95%CI = 1. 01~ 1. 78 38% HR = 1. 38 95%CI = 1. 05 ~ 1. 83 and 36% HR = 1. 36 95%CI = 1. 02~ 1. 82 respectively compared with the cumTyG1 group. The C-index and time-roc results showed that the AUC value of cumulative TyG index exposure was consistently greater than that of single-measured TyG index exposure and tended to be stable throughout the follow-up process. Conclusion High level of cumTyG index exposure is an independent risk factor for CRC. CumTyG exposure has a better predictive value for CRC than single-measured TyG exposure.