Radiation-induced sequelae include early and late sequelae. Late sequelae of radiotherapy result in reduced nutritional status and quality of life which further adversely affects tumor control and survival of oncology patients. Therefore providing appropriate and standardized nutritional management for patients who develop radiotherapy-induced late sequelae is important. Chinese Society of Nutritional Oncology China Society for Radiation Oncology and Radiation Oncology Physicians Branch of Chinese Medical Doctor Association had organized multidisciplinary experts to develop this evidence-based guideline using the Delphi method to form a consensus of expert recommendations and grading the quality of evidence according to the GRADE method. This guideline provides evidence-based advice on the systematic nutritional management of common radiotherapy-induced late sequela for relevant clinical staffs.