Objective The relevance and clinical value between Geriatric nutritional risk index GNRI and long-term prognosis of patients with hepatocellular carcinoma after Transarterial chemoembolization TACE were analyzed. Method A total of 120 patients with hepatocellular carcinoma who received TACE at the First Medical Center of the Chinese People's Liberation Army General Hospital from June 2016 to May 2019 were selected and divided into a survival group 34 cases and a death group 86 cases according to their 3-year survival. The clinical data of the two groups were compared and the influence of clinical data on the long-term prognosis of hepatocellular carcinoma TACE patients was analyzed by Cox regression with survival function and the correlation between GNRI and the long-term prognosis survival time of hepatocellular carcinoma TACE patients was analyzed by Spearman. Result The age of the death group 74. 29±2. 3 was significantly higher than the survival group 71. 40±3. 29 P<0. 05 . The GNRI in the death group 88. 36±3. 69 was significantly lower than that in the survival group 92. 42±3. 54 P<0. 05 . The maximum diameter of tumor cirrhosis distant metastasis and thrombal of vascular tumor in the death group were statistically significant compared with those in the control group P<0. 05 . Death group sex hepatitis B virus surface antigen HBsAg hepatitis C virus HCV TNM stage tumor site liver function Child Pugh grade tumor number AFP ascites invasion of liver capsule coronary heart disease hypertension dilated cardiomyopathy diabetes atrial fibrillation previous stroke hyperlipidemia smoking history drinking history TACE treatment times were not statistically significant compared with survival group P>0. 05 . Cox regression analysis of survival function showed that old age and cirrhosis were risk factors for death in patients with hepatocellular carcinoma treated with TACE P<0. 05 and high GNRI were protective factors for death in patients treated with TACE treated with hepatocellular carcinoma P < 0. 05 . According to Spearman analysis GNRI was positively correlated with survival time of hepatocellular carcinoma patients undergoing TACE P<0. 05 . Conclusion Age cirrhosis and low GNRI are risk factors for death in TACE patients. GNRI may be correlated with the survival time of TACE patients. Early assessment of GNRI can provide a scientific basis for effectively predicting the prognosis of patients.