Objective To discuss the value of controlling nutritional status score CONUT and related indicators in predicting the prognosis of osteosarcoma patients. Method From 2000 to 2018 medical records of 92 patients with osteosarcoma were collected from the First Peoples' Hospital of Yibin and the Second Hospital of Yibin and followed up the clinical outcomes of patients until Dec. 30 2022. ROC curve analysis was used to calculate the cut-off values of SII and CONUT for prognosis prediction Kaplan-Meier method Log-rank test and Cox regression analysis was used to draw survival curves and analyze the influencing factors of prognosis among osteosarcoma patients. Result The medium follow-up time of 92 patients was 58 37 66 months with an medium survival time of 50 23 61 months. The 5-year survival rate was 51. 09% 95%CI = 40. 31%-61. 87% . The area under the ROC curves AUC of SII and CONUT were 0. 726 and 0. 951 respectively with the optimal cut-off values of 671. 66×10 9 / L and 1. 5 points P<0. 01 . Cox regression showed that whether metastasis when diagnosis T stage 3 to 4 and Enneking stage Ⅲ are risk factors of prognosis for patients with HR 95% CI of 2. 751 1. 166 - 6. 491 2. 230 1. 033 - 4. 815 and 4. 889 1. 094 - 21. 854 respectively. CONUT≥2 points are protective factors of prognosis with HR 95%CI of 0. 065 0. 023-0. 184 P<0. 05 . Conclusion CONUT score T stage whether metastasis when diagnosis and Enneking stage are related to the prognosis of osteosarcoma patients while SII is not related to the clinical outcomes of patients with osteosarcoma.