Objective Analyze the application effect of nutritional support management based on anti -inflammatory diet in lung cancer chemotherapy patients. Method A total of 122 patients with lung cancer who received chemotherapy in the First Medical Center of the Chinese People's Liberation Army General Hospital from January 2021 to December 2022 were selected and divided into the control group 61 cases and the experimental group 61 cases by random number table method. The control group was given conventional nutritional support and the experimental group was given nutritional support management based on anti -inflammatory diet. Nutritional status T lymphocyte subsets immune function body weight PG-SGA score Cancer Quality of Life Scale FACT score clinical therapeutic efficacy and adverse reactions were compared between the two groups before and after intervention. Result From the analysis of efficacy and safety the total effective rate of clinical treatment in the study group was 59. 02% which was significantly higher than the 39. 34% in the control group P < 0. 05 . The incidence of adverse reactions in the study group was 16. 39% which was significantly lower than the 39. 34% in the control group P<0. 05 . From the perspective of nutritional status after intervention the study group showed significantly higher levels of albumin ALB 37. 91 ± 3. 28 g / L vs 34. 51 ± 3. 39 g / L total protein PA 389. 24 ± 30. 34 mg / L vs 356. 71 ± 28. 74 mg / L hemoglobin Hb 11. 54 ± 2. 67 g / L vs 8. 63 ± 2. 24 g / L body weight 55. 74 ± 1. 24 kg vs 52. 36 ± 1. 29 kg and quality of life scores The PG-SGA score 5. 28 ± 0. 45 points vs 8. 90 ± 0. 35 points was significantly lower than the control group P<0. 05 . From the perspective of immune function after intervention the CD4 + proportion 38. 53 ± 4. 34 % vs 25. 66 ± 3. 21 % CD4 + / CD8 + proportion 1. 32 ± 0. 38 % vs 0. 63 ± 0. 21 % NK proportion 46. 83 ± 6. 17 % vs 30. 3 ± 4. 33 % IgA IgG and IgM in the study group were significantly higher than those in the control group P<0. 05 . Conclusion Nutritional support management based on anti-inflammatory diet can significantly improve the treatment effect nutritional status and immune function of lung cancer chemotherapy patients and its application safety is guaranteed to a certain extent.