Objective To explore the application effect of personalized nutrition intervention based on WeChat mini-program in postoperative patients with gastric cancer. Method A total of 102 patients who received radical surgery for gastric cancer in a tertiary hospital from January 2022 to December 2022 were selected and randomly divided into intervention and control groups 51 cases in each group. The control group adopted conventional nutritional management measures and the intervention group adopted personalized nutritional intervention based on WeChat mini - programs on the basis of the control group. The patients in the two groups were compared before the intervention 1 month 3 months and 6 months after patient-generated subjective global assessment PG-SGA score the rate of postoperative complications and quality of life scale EORTC QLQ-C30 . Result The nutritional status of patients in the intervention group was better than that of the control group at 1 month 3 months and 6 months after operation and the difference was statistically significant in the group with good nutritional status P<0. 05 . The incidence of postoperative complications in the intervention group was lower than that in the control group. The scores of each dimension of quality of life in the intervention group were higher than those in the control group and the difference was statistically significant P<0. 05 . Conclusion Personalized nutritional intervention based on WeChat mini-program can significantly improve the nutritional status of patients reduce the rate of postoperative complications and improve the quality of life of patients.