Objective To explore the impact of hospital - community - family - based nutritional management program on the nutritional status of head and neck cancer radiotherapy patients. Method 150 head and neck cancer patients who received radiotherapy in Jiangsu Provincial People's Hospital from February 2022 to March 2023 were selected as the study subjects and the patients were divided into the intervention group and the control group using the random number method with 75 patients in each group. The control group was given routine nutritional management and the intervention group was given a hospital-community-family-based nutritional management program and three months after the intervention the patients were evaluated using the patient-generated subjective global assessment PG-SGA nutritional risk screening NRS 2002 to assess the nutritional level of the two groups of patients and t-test / χ 2 test was used to compare the BMI total protein albumin complication rate and severity of the two groups of patients after admission to the hospital and the end of radiotherapy treatment. Result Total protein 67. 62±6. 09 g / L vs 61. 75±5. 28 g / L albumin 37. 78±4. 12 g / L vs 33. 17±3. 98 g / L prealbumin 214. 23±45. 19 g / L vs 191. 08±42. 58 g / L and lymphocyte count 1. 13± 0. 39 × 10 9 / L vs 0. 74± 0. 43 × 10 9 / L were higher than those in the control group P < 0. 05 the complication rate 30. 67% vs 54. 67% and severity 25. 33% vs 56. 67% 5. 33% vs 8. 00% were lower than those in the control group P < 0. 05 and the proportion of patients with low nutritional risk in the intervention group was higher than that in the control group 86. 67% vs 77. 33% P < 0. 05 and the proportion of patients with high nutritional risk was lower than that of the control group 13. 33% vs 22. 67% P < 0. 05 PG-SGA score 6. 98 ± 5. 17 points vs 7. 42 ± 4. 63 points and BMI 20. 93 ± 2. 74 kg / m 2 vs 19. 62 ± 2. 81 kg / m 2 were both better than that of the control group P<0. 05 . Daily energy intake for enteral nutrition was higher in the intervention group than in the control group after the intervention 691. 83±264. 29 kcal vs 348. 12±153. 28 kcal P< 0. 05 . Conclusion The hospital-community-family-based nutritional management program has a good intervention effect on patients with head and neck cancer radiotherapy which can significantly improve the nutritional status and severity of complications.