Objective To investigate the effects of intranasal feeding NGT through nasogastric tube on nutritional status and body status of patients with esophageal cancer during radiotherapy and chemotherapy. Method Retrospective analysis was performed on 100 patients with esophageal cancer who underwent concurrent chemoradiation and chemotherapy treated in the First People's Hospital of Suqian Affiliated to Nanjing Medical University from January 2020 to December 2023. They were divided into 2 groups according to different nutritional therapy methods. The nutritional therapy methods were NGT enteral feeding n = 50 and oral nutritional supplements ONS n = 50 . The nutritional status NRS 2002 and patient-generated subjective global assessment PG-SGA of the two groups were compared before and after 8 weeks of intervention assessment PG-SGA body mass index BMI and related serum nutritional indices body status Karnofsky performance status KPS and incidence of toxic side effects of chemoradiotherapy . Result There was no significant difference in the scores of NRS 2002 PG-SGA and KPS between the two groups before intervention P>0. 05 . After 8 weeks of intervention the scores of NRS 2002 and PG-SGA in NGT group were significantly lower than those in ONS group while the scores of KPS in NGT group were significantly higher than those in ONS group P<0. 05 . Before intervention there was no significant difference in serum nutritional indexes between the two groups P>0. 05 . After 8 weeks of intervention serum ALb Hb Fer and prealbumin levels in NGT group were significantly higher than those in ONS group P< 0. 05 . There was no significant difference in the incidence of toxicity and side effects between 2 groups P> 0. 05 . Conclusion Early NGT nutritional support can effectively improve the nutritional status and physical status of patients with esophageal cancer receiving radiotherapy and chemotherapy and has good clinical application value.