Clinical nutrition is a discipline that aims to promote health prevent and treat diseases by scientifically assessing nutritional needs and adjusting diet and nutrient intake. The clinical nutrition emphasizes the role of diet in maintaining health and treating disease. Now remarkable progress in clinical nutrition attributing to continuous advances in science and technology combined with a deeper understanding in nutrients􀆶 function and metabolism are providing a new impetus and novel ways to prevent and treat various diseases. As the expanding of clinical nutrition research and application nutritional intervention strategies have evolved from traditional dietary recommendations to more refined and individualized management. The utilization of emerging scientific technologies such as genomics and microbiome has enabled to tailor nutritional intervention plans. Moreover nutritional monitoring and management models are also revolutionizing owing to digital health technologies. Emphasized the integration of scientific research and evidencebased medicine modern clinical nutrition aims to update and refine nutritional guidelines through large - scale clinical trials and epidemiological studies. Thus by summarizing the recent progress in nutritional diagnosis and therapy the purpose of this article is to provide a new perspective and strategy for the prevention and therapy of various diseases.