Objective Systemic inflammatory response is closely related to tumor progression. We aimed to investigate the prognostic value of ratio of lymphocyte to C-reactive protein ratio LCR for overall survival OS in patients with non-small cell lung cancer NSCLC . Method 422 NSCLC patients were enrolled in this study. An outcome-oriented Method was used to determine the most appropriate cut - off value of LCR. The participants were divided into two groups a low - LCR group and a high - LCR group. Survival curves were generated using the Kaplan-Meier Method and compared using the log-rank test. We performed subgroup analysis according to histological type adenocarcinoma vs squamous cell carcinoma and TNM stage Ⅰ-Ⅲ vs Ⅳ . Cox proportional hazard regression model was used to calculate hazard ratio HR and 95% confidence interval CI . Moreover We performed subgroup analysis and interaction analysis based on patient characteristics and Cox product interaction analysis to investigate the impact of the interaction between patient characteristics and LCR on the prognosis of NSCLC patients. Result The Kaplan-Meier analysis revealed that patients with high LCR had significantly improved OS P<0. 001 . Patients with high LCR also showed a significantly improved OS P<0. 001 after stratified by histological type and TNM stage. The Cox multivariate analysis showed that patients with high LCR HR= 0. 45 95%CI = 0. 34-0. 61 P<0. 001 had favorable prognoses when compared with those with the lowest LCR. Gender P = 0. 012 smoking P= 0. 002 and histological type P = 0. 012 significantly interacted with LCR indicating that high LCR was a good indicator for male former/ current smokers squamous carcinoma or adenocarcinoma patients. Conclusion High LCR may be associated with a favorable prognosis in NSCLC patients.