Objective To investigate the correlation between nutritional risk index NRI serum ferritin SF soluble E cadherin SE-CAD and prognosis of adult patients with acute myeloid leukemia after allogeneic hematopoietic stem cell transplantation. Method A total of 119 patients with AML who received allogeneic hematopoietic stem cell transplantation in the Second Affiliated Hospital of PLA Air Force Medical University from January 2019 to December 2021 and were followed up until December 2023 were selected as the study subjects and 60 healthy subjects were selected as the control group during the same period. The changes of NRI SF and SE-CAD were compared. Result The NRI of experimental group was lower than that of control group while SF and SE-CAD were higher than that of control group P < 0. 05 . There were significant differences in NRI SF and SE-CAD among different WBC count hemoglobin bone marrow original cell ratio and FAB classification P < 0. 05 . White blood cell count hemoglobin bone marrow original cell ratio and FAB classification were negatively correlated with NRI and SF but positively correlated with SE-CAD and NLR P < 0. 05 . White blood cell count hemoglobin bone marrow original cell ratio and FAB classification were negatively correlated with NRI r = -0. 237 -0. 179 -0. 357 -0. 258 P<0. 05 but positively correlated with SF r = 0. 236 0. 212 0. 190 0. 180 P<0. 05 and SE-CAD r = 0. 328 0. 278 0. 302 0. 256 P<0. 05 . The decrease of NRI and the increase of SF and SE-CAD were independent influencing factors for 3 -year progression - free survival and overall survival of AML patients after surgery P < 0. 05 . The AUC values of NRI SF SE-CAD and three combinations in predicting the prognosis of AML patients were 0. 725 0. 755 0. 756 0. 843 P<0. 05 . Conclusion The abnormal decrease of NRI and the abnormal increase of SF and SE-CAD in patients with acute myeloid leukemia may have adverse effects on prognosis.