Objective To analyze muscle and body fat levels in cirrhotic patients as well as investigate the association between liver disease severity and muscle and body fat in patients with cirrhosis. Method All study participants were cirrhosis patients who were hospitalized at Southwest Medical University's Affiliated Hospital from November 2022 to November 2023. A cross-sectional study was used to collect data on cirrhotic patients' general condition blood routine biochemical tests anthropometric measurements etc. Measurement of skeletal muscle index L3 -SMI visceral fat area VFA and subcutaneous fat area SFA of abdominal CT at the level of the 3rd lumbar vertebrae using Sliceomatic 5. 0 image analysis software. The Geriatric Nutritional Risk Index GNRI was analyzed. VFA and SFA were correlated with L3 - SMI triceps skinfold thickness TSF and mid - arm circumference MAC respectively. To compare the levels of body fat and muscle measured by CT in subgroups with different Child-Pugh classifications and MELD scores. Result A total of 203 patients with liver cirrhosis were included 86 patients with sarcopenia 42. 4% and 117 patients with non-sarcopenia 57. 6% . Body mass index BMI hand grip strength HS MAC TSF calf circumference CC VFA SFA visceral adiposity index VATI and subcutaneous adiposity index SATI were lower in patients with cirrhosis combined with sarcopenia than in patients with non-sarcopenia P<0. 05 . VFA correlating most strongly with MAC r = 0. 595 P<0. 001 and SFA correlating most strongly with TSF r = 0. 753 P<0. 001 . Child-Pugh score grade C had lower VFA SFA VATI and SATI than Child-Pugh score grade A versus B P<0. 05 L3-SMI was not statistically different between groups and all of the above indicators were lower in the MELD score > 11 subgroup than in the MELD score ≤11 subgroup P < 0. 05 and L3 - SMI was again not statistically different between groups. Conclusion When sarcopenia occurred in patients with cirrhosis body fat levels also decreased and decreased with increasing disease severity but no significant changes in muscle levels were observed.