Objective To analyze the influencing factors of early enteral nutrition feeding intolerance in postoperative patients with gastric cancer and to explore the correlation between inflammatory factors and enteral nutrition feeding intolerance in postoperative patients with gastric cancer. Method A total of 200 patients with gastric cancer who underwent radical gastrectomy and early enteral nutrition at the Jiangsu Province Hospital of Traditional Chinese Medicine from June 2022 to April 2024 were selected and their clinical data were retrospectively analyzed. Result In the feeding intolerance group the age was 65. 65 ± 15. 11 years old the nutritional risk screening NRS 2002 score was 3. 31±1. 34 the intraoperative blood loss was 92. 74±48. 36 ml the operation time was 212. 53±48. 51 min and the first time to get out of bed after operation was 4. 58±2. 06 days. The level of prealbumin in the feeding intolerance group was 126. 61±52. 15 g / L which was lower than that in the TEN tolerance group P < 0. 05 . Patients with malnutrition assessed by GLIM were more likely to develop feeding intolerance P < 0. 05 . The levels of TNF-α IL-6 IL-8 IL-1β and CRP in feeding intolerance group were 6. 17±2. 73 pg / ml 48. 29±18. 49 pg / ml 41. 64±16. 34 pg / ml 21. 6±12. 69 pg / ml 70. 42±38. 09 mg / L respectively. They were higher than the enteral nutrition tolerance group P < 0. 05 . Multivariate Logistic regression analysis showed that age NRS 2002 score GLIM score of malnutrition and intraoperative blood loss were risk factors for enteral nutrition intolerance. IL- 6 IL- 8 and IL- 1β are positively correlated with feeding intolerance in postoperative patients with gastric cancer. Conclusion Age NRS 2002 score GLIM score of malnutrition and intraoperative blood loss are the risk factors of feeding intolerance in postoperative patients with gastric cancer. The expression of inflammatory factors is significantly correlated with feeding tolerance.