With the continuous improvement and development of childhood cancer treatment the number of long-term survivors is also increasing. Meanwhile childhood cancer survivors CCSs may face long-term adverse effects of cancer treatment this review delves into the health challenges faced by CCSs and proposes targeted nutritional management strategies to reduce their risk of disease and improve overall quality of life. By analyzing existing literature and research data this paper reveals the health problems of CCSs in endocrine secondary tumors and cardiovascular diseases clinicians and patients need to raise awareness of these complications and it is suggested to form a multidisciplinary team consisting of doctors nurses nutritionists psychologists and other healthcare professionals to provide comprehensive care and support for CCSs.