The methylation of gene in mTOR pathway and tumor energy metabolism

LI Jie-ru; MA Huai-xing; LI Su-yi

doi:10.16689/j.cnki.cn11-9349/r.2016.03.014

Electronic Journal of Metabolism and Nutrition of Cancer >

2016 , Vol. 3 >Issue 3: 186 - 190

DOI: https://doi.org/10.16689/j.cnki.cn11-9349/r.2016.03.014

The methylation of gene in mTOR pathway and tumor energy metabolism

LI Jie-ru ,
MA Huai-xing ,
LI Su-yi

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Online published: 2016-09-02

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Abstract

Abstract: Stimulated by growth factors, hormone and other signals, mTOR plays a critical role in regulating cell proliferation
and differentiation. We reviewed and analyzed literatures, then argued that the methylation of key genes in mTOR signaling pathway
could result in abnormal energy metabolism in cancer, producing aerobic glycolysis, and interfering with protein hydrolysis.
Demethylating genes in mTOR signaling pathway, which might be an entry point to reverse the abnormal energy metabolism in
cancer.

Key words： mTOR signaling pathway; Methylation; Tumor; Metabolism

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LI Jie-ru , MA Huai-xing , LI Su-yi . The methylation of gene in mTOR pathway and tumor energy metabolism[J]. Electronic Journal of Metabolism and Nutrition of Cancer, 2016 , 3(3) : 186 -190 . DOI: 10.16689/j.cnki.cn11-9349/r.2016.03.014

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