Cancer pain refers to tumor, tumor-related symptoms or the pain caused by anti-tumor treatment, and that the occurrence and development of cancer pain are closely related to the nutritional metabolism of the body. Cancer pain affects the body's nutritional metabolism through dietary intake, neuroendocrine system, social psychosocial and so on. In turn, the changes in the body's various nutrients, including vitamins, magnesium and caffeine, curcumin, capsaicin, polyunsaturated fatty acid (PUFA), etc. also have certainly impacts on cancer pain through multiple mechanisms. In addition, abnormal metabolisms of tumor cells are involved in the genesis and development of cancer pain.Among them, the increase of glutamate content is mainly due to the imbalance of oxidation-reduction system in tumor cells and the increase  metabolic level of glutamine (Gln) , and then glutamate promotes persistent transmission of nociceptive signals though mediating transient receptor potential cation channel subfamily V member 1 (TRPV1). This article mainly reviews the interaction between cancer pain and nutrient metabolism, as well as mechanisms related to tumor metabolites causing cancer pain, finally proposes nutrition therapy for patients with cancer pain.