Objective  To investigate the expression of miR-10a and let-7i in endometrial carcinoma tissues and its significance. Methods  Forty cases of endometrial carcinoma，twenty cases of atypical hyperplasia and thirty cases of normal endometrium tissues were collected, poly (A)-RT-qPCR was employed to test the expression of miR-10a and let-7i in different endometrial tissues. The statistical analyses were performed between the expression of miR-10a and let-7i and the clinicopathological characteristics. Results  The expression of miR-10a was higher in endometrial carcinoma tissues than that of normal endometrium and atypical hyperplasia tissues (P<0.01). The expression of miR-10a in patients with grade 3 of pathology was higher than that 1+2, in stage Ⅲ+Ⅳof endometrial carcinoma patients was higher than stageⅠ+Ⅱ, in patients with lymph node metastasis was higher than that without lymph node metastasis , in patients that myometrial invasion≥1/2 was higher than that<1/2. The expression of miR10a in different age, whether ER-positive, PR-positive had no statistical difference (P>0.05).  The expression of let-7i was lower in endometrial carcinoma tissues than that of normal endometrium and atypical hyperplasia tissues (P<0.01)。Conclusions  In endometrial carcinoma tissues, the expression of miR-10a was up-regulated, let-7i was down-regulated, miR-10a may promote invasion and metastasis of endometrial carcinoma.