Distribution law of TCM syndromes and their relationship with immune inflammation in patients with cancer -associated
malnutrition a cross-sectional study
1Department of Oncology Wangjing Hospital of the Chinese Academy of Traditional Chinese Medicine Sciences Beijing 100102
China
2Graduate School Beijing University of Chinese Medicine Beijing 100029 China
Abstract：Objective To investigate the distribution pattern of Traditional Chinese Medicine TCM syndromes in patients with
cancer- associated malnutrition and analyze the correlation between these syndrome types and immune - inflammatory indicators.
Method A cross-sectional study was conducted from August 2022 to January 2025 at the Oncology Department of Wangjing Hospital
Chinese Academy of Traditional Chinese Medicine. A standardized questionnaire was used to collect general information nutrition
impact symptoms physical examination indicators and immune - inflammatory indicators from 191 patients diagnosed with CAM.
Descriptive frequency analysis was performed for NIS the distribution of major TCM syndrome types was summarized based on factor
analysis and cluster analysis and intergroup difference analysis of immune-inflammatory indicators among different TCM syndrome
types in CAM patients was conducted. Result Among the 191 CAM patients xerostomia anorexia and nausea had the highest
frequencies of occurrence with 130 126 and 96 cases respectively. Factor analysis of 11 symptoms identified 4 common factors
with a cumulative contribution rate of 59. 63%. Results of cluster analysis showed that TCM syndrome types were classified into three
categories spleen-stomach yin deficiency syndrome spleen-stomach qi deficiency syndrome and spleen deficiency with dampness
accumulation syndrome. Statistically significant differences P<0. 05 were observed in triceps skinfold thickness total protein white
blood cells count and systemic immune-inflammation index among the three syndrome types. Secondary analysis revealed that TSF in
patients with spleen deficiency with dampness accumulation syndrome was lower than that in patients with spleen-stomach qi deficiency syndrome TP appetite visual analog scale score neutrophils and SII in patients with Spleen-stomach qi deficiency syndrome were
higher than those in patients with spleen - stomach yin deficiency syndrome while the PG- SGA score was lower all P< 0. 05 .
Conclusion This study found that the main TCM syndrome types in CAM patients are spleen - stomach yin deficiency syndrome
spleen-stomach qi deficiency syndrome and spleen deficiency with dampness accumulation syndrome. Patients with spleen-stomach
yin deficiency syndrome have the most severe CAM patients with spleen - stomach qi deficiency syndrome present a more severe
inflammatory state and patients with spleen deficiency with dampness accumulation syndrome show the most significant reduction in
muscle mass. In conclusion for CAM patients TCM treatment should be based on " strengthening the spleen " combined with
replenishing qi nourishing yin and resolving dampness to regulate immune-inflammatory levels and improve malnutrition.
1,2宗铭桐,1,2 谢虹亭,1,2 赵乐怡,2 李 晴,1 薛 鹏,1 朱世杰. 肿瘤营养不良的中医证型分布规律及与免疫炎症关系研究[J]. 肿瘤代谢与营养电子杂志, 2025, 12(6): 754-760.
1,2Zong Mingtong,1,2Xie Hongting,1,2Zhao Leyi,2Li Qing,1Xue Peng,1Zhu Shijie. Distribution law of TCM syndromes and their relationship with immune inflammation in patients with cancer -associated
malnutrition a cross-sectional study. Electron J Metab Nutr Cancer, 2025, 12(6): 754-760.
