摘要：目的 评价口服水解蛋白应用于消化道肿瘤患者的疗效。方法 采用前瞻随机对照研究，共纳入60例营养不良的消化道肿瘤患者，随机分为试验组和对照组，各30例。试验组接受常规营养支持，同时每天口服30g水解蛋白；对照组仅接受常规营养支持。两组连续营养支持7d后检验相关营养指标，比较两组在营养支持前后相关指标的差异。结果 两组营养支持过程中胃肠道症状发生率无统计学差异（P＞0.05）。营养治疗后试验组淋巴细胞计数、血红蛋白、总蛋白、白蛋白、球蛋白、前白蛋白、转铁蛋白、高密度脂蛋白均比治疗前增高（P＜0.05）；而C反应蛋白水平较治疗前下降（P=0.031）。对照组中仅前白蛋白与治疗前相比明显增高（P=0.028）。营养治疗后，试验组中总蛋白、白蛋白、前白蛋白、转铁蛋白比对照组提高更明显，差异有统计学意义（P值分别为0.013、0.001、0.045、0.048）。结论 常规营养支持联合口服水解蛋白在营养不良的消化道肿瘤患者中有良好的依从性和耐受性，能更好的改善患者的营养状态。?

Abstract：Objective To evaluate the therapeutic efficacy of oral hydrolyzed protein in the patients with gastrointestinal cancer. Methods Sixty cases of gastrointestinal cancer patients were prospectively included and then randomly divided into experimental group and control group; There were thirty cases in each group. The experimental group received routine nutritional support with daily oral 30g hydrolyzed protein; the control group only received routine nutritional support. Two groups accepted seven days continuous treatment. Hereafter we tested the related nutrition indicators and compared the differences between before and after treatment in two groups. Results During the treatment, the ratios of gastrointestinal complications in two groups were no significant difference. After nutritional support, the lymphocyte count, hemoglobin, total protein, albumin, globulin, pre-albumin, transferrin and HDL cholesterol in experimental group were higher than before treatment, but C-reactive protein was lower than before, the difference was statistically significant (P=0.031). However, compared with before treatment, only pre-albumin in control group was significant difference (P=0.028). After treatment, total protein, albumin, pre-albumin and transferrin in test group improved higher than control group (P=0.013, 0.001, 0.045, 0.048, respectively). Conclusions Common nutritional therapy, which combines with oral hydrolyzed protein in malnourished patients with gastrointestinal cancer, has a well adherence and tolerability and improves the patients' nutritional status.